Closed head injury in rats: histopathological aspects in an experimental weight drop model
نویسندگان
چکیده
منابع مشابه
Closed head injury in rats: histopathological aspects in an experimental weight drop model.
PURPOSE To study histopathological findings due to a model of closed head injury by weight loss in rats. METHODS A platform was used to induce closed cranial lesion controlled by weight loss with a known and predefined energy. 25 male Wistar rats (Rattus novergicus albinus) were divided in five equal groups which received different cranial impact energy levels: G1, G2, G3 and G4 with 0.234J, ...
متن کاملP87: Closed Traumatic Brain Injury Model in Sheep Mimicking High-Velocity, Closed Head Trauma in Humans
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متن کاملp87: closed traumatic brain injury model in sheep mimicking high-velocity, closed head trauma in humans
there are only a few, non-evidence based, neuroprotective strategies for treatment and prevention of brain injuries after closed head trauma. to establish new therapy strategies, a novel animal model is needed. the aim of our investigation was to link standardized small animal models and actual patient medical care. data of experimental small animal studies often cannot be transferred to cns in...
متن کاملInduction of Fos protein in a model of closed head injury in rats.
The induction of Fos immunoreactivity in the pyriform cortex and the hippocampal formation after closed head injury was determined and compared to that seen following cortical needle injury in pentobarbital anaesthetized male rats. Robust Fos expression was observed in the ipsilateral pyriform cortex following both types of injury but was observed in the ipsilateral dentate gyrus only following...
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ژورنال
عنوان ژورنال: Acta Cirurgica Brasileira
سال: 2012
ISSN: 0102-8650
DOI: 10.1590/s0102-86502012000400002